ZFIN Image: Vetrivel et al., 2019, Fig. 8

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Figure Caption

Fig. 8

Changes in the expression patterns of the transcription factors PITX3 and FOXE3 in the Aey69 mutant lens. a) The transcription factor PITX3 was used to characterize the alteration in lens development from E11.5 -E14.5, when the lens structure diminishes. Similar to CRYAA, for PITX3 at E11.5 there was no major change in the distribution in the wild type and mutant lens (marked by their respective white arrows) and through the stages of E12.5 – E14.5 the arrows highlight clearly the diminishing PITX3 expression in the shrinking mutant lens. The bars indicate 100 μm (n = 3 for each embryonic stage). L, lens; R, retina; ON, optic nerve. b) The lens-specific transcription factor FOXE3 was used to identify any disruptions in lens development starting from E11.5. The arrows marking the mutant lens at E11.5 clearly indicate reduced expression of FOXE3 at E11.5. The bars indicate 50 μm; n = 3 for each embryonic stage; L, lens; R, retina; ON, optic nerve.

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Reprinted from Experimental Eye Research, 188, Vetrivel, S., Tiso, N., Kügler, A., Irmler, M., Horsch, M., Beckers, J., Hladik, D., Giesert, F., Gailus-Durner, V., Fuchs, H., Sabrautzki, S., German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany, Adler, T., Treise, I., Busch, D.H., Aguilar-Pimentel, A., Ollert, M., Götz, A., Amarie, O.V., Stoeger, T., Schulz, H., Becker, L., Klopstock, T., Schrewe, A., Spielmann, N., Bekeredjian, R., Garrett, L., Hölter, S.M., Zimprich, A., Wurst, W., Mayer-Kuckuk, P., Hans, W., Rozman, J., Klingenspor, M., Neff, F., da Silva-Buttkus, P., Calzada-Wack, J., Rácz, I., Zimmer, A., Rathkolb, B., Wolf, E., Prehn, C., Adamski, J., Östereicher, M., Miller, G., Steinkamp, R., Lengger, C., Maier, H., Stoeger, C., Leuchtenberger, S., Gailus-Durner, V., Fuchs, H., Hrabě de Angelis, M., Hrabě de Angelis, M., Graw, J., Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia, 107632, Copyright (2019) with permission from Elsevier. Full text @ Exp. Eye. Res.