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Fig. S11
foxc1a and foxc1b compound mutant morphology. Lateral images at 48 hpf (A) and 96 hpf (B), showing increasing cardiovascular insufficiency (pericardial edema, hydrocephalus) with progressive loss of foxc1a/foxc1b alleles. At 48 hpf, there is little morphological difference among all genotypes, except for mild edema in foxc1a mutants. At 96 hpf, there is severe edema in foxc1a-/- embryos, with the most severe phenotype with additional loss of foxc1b alleles. Scale bar represents 50 µm for all panels.
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Reprinted from Developmental Biology, 453(1), Whitesell, T.R., Chrystal, P.W., Ryu, J.R., Munsie, N., Grosse, A., French, C.R., Workentine, M.L., Li, R., Zhu, L.J., Waskiewicz, A., Lehmann, O.J., Lawson, N.D., Childs, S.J., foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish, 34-47, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.