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Figure S1
Depletion of cdh2 leads to defective neurulation and abnormal apicobasal polarity (a-b) Maximum projections of dorsal confocal pictures showing abnormal neural tube morphology and disorganised apical midline seam specialisation in cdh2/pac by 24 hpf, as revealed by apical marker, ZO-1 (arrows). Anterior is up. (c-d) Cross-section analysis in cdh2/pac mutants reveal disrupted apical midline seam organisation (arrowheads) at hindbrain levels.
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