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Fig. 7
Anxiety-like behavior in Ntrk2b mutants. (A) Dark- light -dark activity test of 6 dpf Ntrk2b mutant larvae with 10 mins interval between the sessions. Each session was divided into blocks of two. (B) Acoustic startle responses of 6 dpf Wt and mutant larvae. (B) (a) Mean value of the maximum velocity during 10 stimuli with a 20 s ISI. (C) Analysis of acoustic startle response during 30 stimuli with a 1 s ISI. (D) Novel tank diving test using Ntrk2b adult mutants 9 months old. Distance travelled in the bottom of the tank by the mutant is significantly higher. (E) Latency to move to the top of the tank is higher in the mutants. (F) Locomotor activity of Ntrk2b adult mutants. (G) The locomotor activity of Ntrk2b morphants larvae. (Bars represent Mean ± SEM, two-way ANOVA with repeated measures: *p < 0.05, **p < 0.01, ***p < 0.001; ISI- inter stimulus interval).