ZFIN Image: Gjini et al., 2019, Fig. 2.

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Figure Caption

Fig. 2.

Asxl1 loss affects organ development. Histopathological analysis of the muscle, intestine and liver development with hematoxylin and eosin staining in 5 asxl1^+/+ and 5 asxl1^−/− mutants at 6 dpf and 14 dpf. Muscle (A,D) and intestine (B,E) development had no difference between asxl1^+/+ and asxl1^−/− embryos at 6 dpf. Liver parenchyma at 6 dpf appeared abnormal with vacuolated cells in asxl1^−/− embryos (F) compared with asxl1^+/+ embryos (C). At 14 dpf, muscular atrophy was shown in asxl1^−/− embryos (J) compared with normal striated muscle in asxl1^+/+ embryos (G). Intestine in asxl1^−/− embryos was abnormal with villus blunting (K) compared with normal nuclei and microvilli in the asxl1^+/+ embryos (H). The asxl1^−/− embryos exhibited progressive liver architectural distortion (L) compared to asxl1^+/+ embryos (I).

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.