ZFIN Image: Wafer et al., 2017, Figure 1

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Figure Caption

Figure 1

Overview of peroxisome proliferator-activated receptor gamma (PPARG) structure, DNA-binding specificity, and identification of human PPARG genetic variation conserved to fish. (A) Schematic illustrating the domain organization of human PPARG. (B) PPARG:RXRA-binding motifs for human (upper motif) and mouse (lower motif). Motifs are derived from the JASPAR database (http://jaspar.genereg.net/). (C) PPARG domain structure with dbSNPS predicted to be deleterious using SIFT and Polyphen, and conserved to zebrafish, Nile tilapia, and fugu. Red single nucleotide polymorphisms (SNPs) indicate functional verification (9). Yellow–brown histogram indicates the degree of conservation in PPARG between human, mouse, coelacanth, spotted gar, zebrafish, fugu, and Nile tilapia. Height and color indicate the degree of conservation.

Acknowledgments

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