ZFIN Image: van der Weyden et al., 2016, Figure 1

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Figure Caption

Figure 1

Established melanoma pathways. The two major signalling pathways implicated in melanoma are the mitogen‐activated protein kinase and the phosphatidylinositol‐4,5‐bisphosphate 3‐kinase pathways, which are in red and green, respectively. Key genes include c‐KIT (pink), CDK (blue), GNAQ/GNA11 (brown), MITF (orange), NRAS (yellow), and P53/BCL (purple). MC1R, which is involved in skin pigmentation, and TERT and POT1, which are involved in telomere regulation, are also shown. This figure was modified from Vidwans et al142 under the Creative Commons Attribution License. The lines shown indicate known interactions between pathways or molecules.

Acknowledgments

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