Fig. 7.

Fig. 7.

Ribbon representation of models of zebrafish Fgf3 isoforms bound to a FGF1 receptor. (A) Ribbon representation of a zebrafish Fgf3 model (blue and pink) bound to a FGF1 receptor (yellow). The overall part affected by the fgf3^t24152 mutation or the fgf3 morpholino is coloured in pink. (B) The deleted region of the fgf3^t24152 mutant isoform is omitted. The part that remains (green) as compared to the morpholino knockdown isoform still folds. Notably, receptor binding would be still possible if the variant maintains partial folding, since most of the interfaces with the FGF1 receptor would stay intact. (C) Model of the morpholino knockdown. The exchanged sequence is coloured in red. In comparison to the fgf3^t24152 mutant model it lacks even more structural elements rendering a correct folding and residual receptor interactions less likely.