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Fig. 6
Glomerular filtration is impaired in nup133 morphants. Representative images of cross sections of 4 dpf control (left panels) and nup133 morphants larvae (right panels) fixed 20 minutes after injection of Alexa Fluor™ 647 conjugated-BSA into the common cardinal vein. Lower panels represent a higher magnification view of the proximal tubule region (dotted lines). Note the uptake of fluorescent BSA in the apical endosomes of the proximal tubules of the Nup133-depleted larva (arrows). Scale bars 50 µm.
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