ZFIN Image: Posner et al., 2019, Fig. 6

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Figure Caption

Fig. 6

Percent of embryos with lens GFP expression after injection of zebrafish αA-crystallin promoter/GFP and human βB1-crystallin promoter/GFP plasmids.

Data show that the native αA-crystallin promoter drives greater GFP expression in lens compared to the human bB1 promoter in cloche and non-phenotype siblings (Yates Corrected X² test: X² = 16.85, p value<0.001; X² = 21.38, p value<0.001 respectively), but this difference was not statistically significant in wildtype embryos (X² = 3.35, pvalue>0.05). Each box and whisker blot represents two independent experiments (except for the βB1 sibling value which included three independent experiments). Each independent experiment included between 3 and 54 embryos at 4 dpf (median = 19). Inset shows an example of GFP lens expression in a cloche embryo produced by the αA-crystallin promoter.

Acknowledgments

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