Fig. S11
The CoupTFII-965 enhancer is active in zebrafish a-c Relating directly to Figure 7c, further representative fish from the stable transgenic line tg(CoupTFII-965:GFP;kdrl:HRAS-mCherry) at 24hpf (a), 48hpf (b) and 72 hpf (c, partially also shown in Fig. 7c). d. IGV view of the human sequence orthologous to the Coup-TFII enhancer and surrounding region. Morikawa et al. 11 SMAD1/5 ChIP-seq data in HUVEC (BMP9 stimulated) is displayed as Bam coverage (pink peaks), Bam reads (grey boxes) and Bedgraph (red peaks). The exact sequence corresponding to Bam coverage peaks is shown in full, mouse sequence on top, human sequence on bottom, * denoting conserved bp . Motifs are marked: SBE (blue), GC-SBE (green) and other SMAD1/5- bound MEMEs (grey).