ZFIN Image: Lan et al., 2019, Fig. S6

Image

Figure Caption

Fig. S6

Inhibiting the Activin-A Pathway or sox9b Causes AVC Disruption and PE Migration Defect. Related to Figure 5.
(A-D) WISH for AVC markers has2 and bmp4 at 48-hpf in wildtype or TRIM treated larvae.
(E-F) GFP-labeled AVC endocardium represents Wnt activity in wildtype but not TRIM treated heart. Hearts were dissected from 48-hpf larvae carrying the Tg(7xTCF-Xla.Siam:GFP) transgene.

(G) Number of epicardial cells in the heart of 4-dpf sibling, sibling exposed to SB431542 or TRIM from 24 hpf,sox9b morphant and tet2/3DM larvae carrying the Tg(tcf21:NLS-EGFP) transgene. Data are presented as the mean ± SD. The significance is indicated as **P < 0.01.
Scale bar: 50μm.

Acknowledgments

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