ZFIN Image: Yang et al., 2019, Fig. S2

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Fig. S2

Characterization of early heart development and primitive erythropoiesis in zfpm1-/- embryos. (A) Morphology of embryonic hearts (revealed by Tg(myh7: GFP) transgene ) in indicated genetic backgrounds at designated time points. Arrows indicating the initiation of trabecular. Ventral views with anterior to the top. Scale bar: 200μm. (B) Endocardium and cardiac valve development are observed in live control and zfpm1-/- embryos by introduction of Tg(kdrl: GFP) transgene. Red arrowhead indicated the stenosis in zfpm1-/- heart. White arrowheads indicated superior and inferior valve leaflets. Ventral views with anterior to the top. Scale bar: 200μm. (C) Whole-mount embryo o-dianisidine staining showed transient abnormal erythropoiesis in zfpm1-/- embryos. Ventral views with anterior to the top. Scale bar: 200μm. (D) RNA in situ hybridization is shown for cardiogenic regulatory gene expression in control and zfpm1 mutant zebrafish embryos at 36 hpf; frontal views with dorsal side to the top. Scale bar: 20μm.

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Acknowledgments

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Reprinted from Developmental Biology, 446(2), Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X., The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling, 142-150, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.