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Fig. 7
Heatshock inducible overexpression of Etv2 induces ectopic flt4 and lyve1b expression. (A,B) Embryos injected with hsp70:Etv2-mCherry overexpression construct show ectopic induction of flt4 (B) in the somites (arrows) following the heat-shock compared to uninjected controls (A). (C,D) Ectopic expression of lyve1b over the yolk is apparent in a subset of embryos that overexpress hsp70:Etv2-mCherry (arrows, D). (E-H) No ectopic induction of fli1a (E,F) or prox1a (G,H) was apparent in the embryos that overexpress hsp70:Etv2-mCherry. All embryos are at 28–30 hpf.
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Reprinted from Developmental Biology, 440(1), Davis, J.A., Koenig, A.L., Lubert, A., Chestnut, B., Liu, F., Desai, S.P., Winkler, T., Pociute, K., Choi, K., Sumanas, S., ETS transcription factor Etsrp / Etv2 is required for lymphangiogenesis and directly regulates vegfr3 / flt4 expression, 40-52, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.