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Fig. 6
SMAD9 zebrafish morphant cranial circulation. Confocal source data set images of the cranial circulation in a representative SMAD9 translation-blocking morpholino-injected Tg(kdrl:eGFP) zebrafish embryo at 72 h post fertilization. In addition to the numerous abnormal arteriovenous connections previously observed in Figure 4f, other cerebrovascular changes were also present. There was a paucity of central arteries that penetrate the hindbrain and usually connect the basilar artery and posterior hindbrain channel. The lateral dorsal aorta was also significantly dilated and irregular.
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