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Fig. S1
Notch-mediated lateral inhibition of atoh1c MHB domain. Pharmacological inhibition of Notch signaling with g-secretase inhibitor DAPT blocks restriction of atoh1c expression domain (B) resulting in an overproduction of Tg(atoh1c::kaede)+ neurons (D) compared to stage-matched vehicle treated control embryos (A,C). 22 hpf embryos (A,B) treated for 18 hours or 30 hpf embryos (C,D) treated for 26 hours in orientations as indicated.Red arrowheads indicate location of MHB. Scale bars: 50 uM.
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Reprinted from Developmental Biology, 438(1), Kidwell, C.U., Su, C.Y., Hibi, M., Moens, C.B., Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum, 44-56, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.