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Fig. S2
Generation of second nr2f1a deletion allele. (A) Schematic of deletion in nr2f1a exon 2 induced from the CRISPR/Cas9. (B) Sequence of the 49-bp deletion in the nr2f1aci1009 mutant allele. (C) Schematic indicating the predicted truncation caused by the out of frame deletion. (D,E) WT and nr2f1a ci1009-/- mutant embryos at 48 hpf. Arrow indicates blood pooling and edema on yolk.
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Reprinted from Developmental Biology, 434(1), Duong, T.B., Ravisankar, P., Song, Y.C., Gafranek, J.T., Rydeen, A.B., Dohn, T.E., Barske, L.A., Crump, J.G., Waxman, J.S., Nr2f1a balances atrial chamber and atrioventricular canal size via BMP signaling-independent and -dependent mechanisms, 7-14, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.