ZFIN Image: Rogers et al., 2017, Fig. 1-S1

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Figure Caption

Fig. 1-S1

lefty1^-/- mutants exhibit partially penetrant heart laterality defects.

(A) In situ hybridization using a probe against the heart muscle marker myl7 in 24 hr post-fertilization (hpf) wild type and lft mutant embryos (dorsal views). Most wild type and lft2^-/- mutants exhibit myl7 expression on the left side. In contrast, some lft1^-/- mutants exhibit bilateral myl7 expression, and lft1^-/-;lft2^-/- mutants express very little myl7 and typically fail to generate hearts (dorsal views). (B) Quantification of heart laterality defects in lft1^-/- and lft2^-/- mutants (ventral views). Live embryos were scored at 30 hpf. Whereas lft2^-/- mutants typically exhibit normal heart laterality, lft1^-/- mutants frequently have misplaced hearts. Despite this heart laterality defect, lft1^-/- mutants are viable.

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Acknowledgments

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