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Fig. 5
Metformin increases AMPK levels in pkd2 morphants. (A) Representative Western blots for phospho-Thr172 AMPK, total AMPK, and β-actin in total embryo lysates from mismatch MO-injected controls and pkd2 morphants with and without metformin (10 mM) treatment at 48 hpf. (B) Quantification of p-AMPK relative to total AMPK through densitometric analysis of Western blots; n = 9 from five independent experiments. *P < 0.05, n.s. = not significant. Cropped blot images are shown, and all the blots were run under the same experimental conditions. Uncropped blots are shown in Supplementary Fig. S2.
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