ZFIN Image: Shen et al., 2017, Fig. S3

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Figure Caption

Fig. S3

Analysis of zygotic mutants at 24 hpf. (A-E) Bright-field lateral view of wildtype and ikk2^-/- (zygotic) embryos obtained from heterozygotic parents with notochord defects at 24 hpf. A, wild-type embryos. B-E, ikk2^-/- embryos classified into four categories based on severity of the notochord defects. Class I and II show notochord defects and Ushaped somites. Class III and IV show mild notochord defects and increased turbidity of the brain suggestive of apoptosis. (F-H) Lateral view of embryos stained by in situ hybridization using ntl probe. ikk2^-/- embryos have either crooked notochord or its truncation. Scale bar: 250 μm.

Acknowledgments

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