ZFIN Image: Chang et al., 2017, Fig. 3

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Figure Caption

Fig. 3

Loss of ftr82 showed edema, circulation defect, and absent parachordal chain. (A,B) At 48 hpf, ftr82 morphants showed incomplete ISV ((B), yellow hollow arrows) and absent parachordal chain (PAC) formation ((B), hollow arrowheads) compared to control (A) by using Tg (fli1a:eGFP)^y1 fish; (G) Quantification of PAC formation with normal (arrowheads in (A)), partial growth (arrows in (A)) or absence (hollow arrowhead in (A)); (C–F) At 72 hpf, representative embryos showed loss of ftr82, resulting in an increasing edema in the brain (arrowhead in (E)) and pericardium (arrows in (E,F)) or blood accumulation at CVP (arrow in (D)); (H) Quantification of ftr82 morphants showed ~90% of embryos with circulation defects in the axial vessels and/or ISVs-DLAVs (n = 38 in control and n = 45 in ftr82 MO); and (I) 80% of ftr82 morphants (n = 31) with mild to severe edema and/or blood blockage compared to control (n = 28). The scale bars in (A,B) represent 200 μm and in (C–F) are 500 μm.

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Acknowledgments

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