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Fig. S3
Inhibition of N-‐CISSOR cleavage in zebrafish embryos. (a) Representative image of Tg (SAIGFF213A; 5×UAS-‐N-‐CISSOR MUT) at 36 hpf. Scale bar: 10 μm. (b) Western blot analysis of the inhibition of N-‐CISSOR cleavage following treatment with an inhibitor cocktail (0.5 μM GM6001 and 0.1 μm BACE inhibitor IV; dissolved in DMSO) for 4 h. f. l.: full-‐length; c. f.: cleaved fragment. (c) GFP image of CaP neurons in Tg (SAIGFF213A; 5×UAS-‐N-‐CISSOR) treated with an inhibitor cocktail (0.5 mM GM6001 and 0.1 mM BACE inhibitor IV; dissolved in DMSO) obtained between 25 and 36 hpf. Scale bar: 20 μm
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