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Fig. S8
Expression profiling of SOX7/18 mutant mice and zebrafish mophants. (A) Wholemount in situ hybridization assay showed a reduction of Notch1 expression in the primitive heart cavity and dorsal aorta (asterisks) in Sox7/Sox18 double knockouts at 8.5dpc (8-11ss) compared to the WT control and Sox7-/-; Sox18+/- control (black arrows). ht = heart, da = dorsal aorta. (B) Wholemount in situ hybirdization showed a comparable cdh5 expresison between control and sox7/18 double morphants, indicating that vascular structures were correctly formed in these morphants.
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