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Fig. 9
brca2overexpression is sufficient to partially rescuezepand also induces ectopic podocytes in wild-type embryos. Overexpression of full-length brca2 cRNA partially restored expression of (A) wt1b and (B) nphs1 in zep -/- and was associated with the induction of ectopic podocytes in a small percentage of WT siblings (see text for incidence). Embryos are shown in dorsal views with insets showing digital zoom of 150%, where black boxes demarcate the cervical region where the podocytes develop.
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Reprinted from Developmental Biology, 428(1), Kroeger, P.T., Drummond, B.E., Miceli, R., McKernan, M., Gerlach, G.F., Marra, A.N., Fox, A., McCampbell, K.K., Leshchiner, I., Rodriguez-Mari, A., BreMiller, R., Thummel, R., Davidson, A.J., Postlethwait, J., Goessling, W., Wingert, R.A., The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development, 148-163, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.