ZFIN Image: Theodore et al., 2017, Fig. S7

Image

Figure Caption

Fig. S7

Mmp9 inhibition does not impact HSPC localization in cxcl12a heterozygous mutants.

Related to Figure 7.

A) Exposure of wild-type (WT) sibling controls to MMP9-I (5μM, 12-72 hpf) increased cmyb expression in the CHT at 72 hpf; in contrast, while heterozygous loss of cxcl12a in cxcl12a^{t30516/t30516} (cxcl12a^+/-) embryos had no impact on cmyb expression alone, it antagonized the effect of Mmp9 inhibition (n≥20/condition).

B) Qualitative phenotypic distribution of control and MMP9-I treated WT and cxcl12a^+/- siblings from S7A scored with high/medium/low cmyb expression at 72 hpf (n≥20/condition).

Scale bars: 100μm.

Acknowledgments

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