ZFIN Image: Zhang et al., 2015, Fig. S5

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Figure Caption

Fig. S5

Gpr183 regulates HE/HSC development specifically.(A) The expression of mesoderm markers sox17, ntl and ectoderm marker gsc do not altered in gpr183 morphants at 75% epiboly. (B) The expression of niche cells markers, including somite marker myod, endothelial cell marker flk1, pronephric duct marker pax2.1 and venous marker msr, do not altered in gpr183 mutants. (C) BrdU assay in Tg(fli1a:eGFP) embryos after knocking down gpr183 (n=8 for each). (D) Time-course TUNEL assay in Tg(fli1a:eGFP) embryos after blocking gpr183 signaling (n=6 for each). White rectangles mark the proliferative or apoptotic cells in the AGM.

Acknowledgments

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