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Fig. S5
Independently derived prrx1a; prrx1b mutants confirm specificity of skeletal phenotype.
(A, B) Independently derived prrx1ab1246; prrx1bb1247 double mutants (B, B') phenocopy prrx1ael558; prrx1bel491 mutants (Fig 7B). Note the expanded cartilage in the palatoquadrate (black arrowhead) and the fusions between the hyomandibula and otic cartilage (black arrow). Scale bar = 100 μm. (C) Schematic of prrx1a/b TALEN (el558, el491) and CRISPR (b1246, b1247) alleles. In all cases, the mutant allele produces a frameshift (black) and premature stop codon upstream of the homeobox (Hx) and OAR domains (O).
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