ZFIN Image: Venero Galanternik M. et al., 2016, Fig. S5

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Figure Caption

Fig. S5

Changes in Hh and Bmp signaling in glypican4^fr6 mutants affect the expression of cxcl12a along the myoseptum. (A–C) Expression of cxcl12a in siblings (A) and glypican4^fr6 mutants (B, C). In mutants gaps in cxcl12a expression persist until 48 hpf when the primordium migration is completed. (D–I) The Hh target gene patched2 becomes increasingly downregulated in glypican4^fr6 mutants as the embryos develop. (J–U) On the other hand, the Bmp target gene id1 only shows signs of upregulation at around 18 hpf which becomes more severe by 38 hpf when the glypican4^fr6 mutant primordia have completed their migration.

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Reprinted from Developmental Biology, 419(2), Venero Galanternik M., Lush, M.E., Piotrowski, T., Glypican4 Modulates Lateral Line Collective Cell Migration Non Cell-Autonomously, 321-335, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.