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Fig. 6
TGF-β signaling is activated in Collagen XII-positive fibrotic tissue.
(A-C) Analyses of ventricle sections at 14 dpci. (A) In -situ hybridization detects tgf-β2 expression in the cryoinjury area. N = 5. (B, C) Immunofluorescence staining reveals co-distribution of Col XII fibrils (green) and p-Smad3 (red) in the post-cryolesion zone that is recognized by the absence of Tropomyosin (blue in B). p-Smad3 reactivity is detected in the nuclei visualized by DAPI (blue in C). N = 5.
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