ZFIN Image: Marro et al., 2016, Fig. 5

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Figure Caption

Fig. 5

The multi-component matrix of the fibrotic post-cryoinjury tissue is rich in Collagen XII.

(A) Heart section of transgenic fish wt1a(-6.8kb):GFP (red) at 14 dpci. (A’) Subepicardial fibroblasts (red) co-localize with Col XII deposition (green). (A'') The injury zone contains wt1a(-6.8kb):GFP-positive cardiac fibroblasts that are associated with Col XII-positive matrix. N = 5. (B-G) Higher magnifications of fibrotic wound tissue of sections at 14 dpci that were triple immunostained and then used for histological coloration with AFOG. The intact myocardium is detected by Tropomyosin staining (blue); Col XII (green). (B, D, and F) AFOG staining of the corresponding sections used for immunostaining. (C) Col XII and Col Iα (red) are co-distributed in the post-cryoinjured area. (E) Col XII and Tenascin C (red) partially co-localize. (G) Fibronectin (red) partially overlaps with Col XII. N ≥ 4.

Acknowledgments

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