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Fig. 4
Overexpression of fgf8a synergizes with mutation of p53 in MPNST development. Kaplan–Meier curves indicate when externally visible tumors were first observed in fish with the indicated genotypes. All fish were progeny of the same four pairs born the same day. Tumor type was confirmed by histological analysis, and fish with neuroblastoma (1 in p53 HOM, HagD1 het, 1 in p53 het, HagD1 het) were excluded from the analysis. No MPNSTs were found in p53 WT, HagD1 heterozygous fish. P values comparing genotyped pairs are shown.
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Full text @ Proc. Natl. Acad. Sci. USA