ZFIN Image: Li et al., 2015, Fig. 6

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Figure Caption

Fig. 6

impdh2 mediates the circadian control of cell cycle.

(A) The BrdU staining in 5 dpf larvae represents the daily rhythm of S phase in cell cycle under LD conditions. (B) The amplitude of the S phase rhythm was attenuated when the larvae were treated with MPA. The effect of MPA was rescued when guanosine was added to MPA-treated larvae. The inhibitory effect of MPA on the S phase rhythm was in a dose-dependent manner and saturated at 10μM concentration. (C) The amplitude of the S phase rhythm decreased significantly in impdh2 morphants. At least three larvae were measured at each data point. Error bars represent the standard error of mean (SEM) among independent biological replicates. Scale bars, 200μm.

Figure Data

Phenotype details

Acknowledgments

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