ZFIN Image: Marín-Juez et al., 2016, Fig. 1

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Figure Caption

Fig. 1

The zebrafish heart displays fast revascularization of the damaged area. (A-C) Tg(fli1a:EGFP) ventricles at 0, 15, and 40 hpi. White arrowheads point to coronary vessel sprouts in the injured area; asterisk marks an area of coronary plexus (n = 4). Insets show high-magnification images of early coronary sprouts (B) and the coronary plexus (C). (D) Tg(kdrl:EGFP) heart at 15 hpi (n = 3). (E and F) Tg(fli1a:EGFP);Tg(kdrl:mCherry) ventricles extracted at 0 hpi and cultured in explant medium for 24 h (0+24 hpi) (n = 3). White arrowhead points to kdrl:EGFP⁺ vessels sprouting into the injured area. Inset shows overlay image of a sprouting coronary vessel. White arrows point to fli1a:EGFP⁺/kdrl:mCherry⁺ coronary vessel sprouting into the injured area. (G) Tg(Dll4in3:TagRFP) ventricle at 40 hpi (n = 5). Inset shows a Dll4in3:TagRFP⁺ sprouting coronary artery. (H and I) Tg(cxcr4a:YFP) ventricles at 40 hpi (n = 3) and 7 dpi (n = 4). Insets show cxcr4a:YFP⁺ sprouting coronaries; white arrowheads point to coronary arteries sprouting into the injured area. Dotted lines delineate the injured area. (Scale bars: 50 µm.)

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Expression / Labeling details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA