ZFIN Image: Cox et al., 2016, Fig. 6

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Fig. 6

seph genetically interacts with p53 deficiency to accelerate GI tumor formation. (A) Scheme illustrating the protocol used to study DMBA-induced tumorigenesis. (B) Example of a GI tumor in a tp53^-/-;seph^+/- fish exposed to DMBA. (Scale bar: 2 mm.) (C) Kaplan-Meier analysis of Tumor-free survival in tp53^-/- and tp53^-/-;seph^+/- fish exposed to DMBA. n > 25 fish. P = 0.0344, Mantel-Cox log-rank test. (D) The incidence of pancreatic cancer, liver cancer, intestinal cancer, and malignant spindle cell neoplasm in tp53^-/- and tp53^-/-;seph^+/- fish exposed to DMBA. (E) Histological evaluation of GI tumors identified in tp53^-/-;seph^+/- fish showing examples of PACC, HCC, and malignant spindle cell neoplasm (MSCN). (Scale bar: 100 µm.)

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA