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Fig. 7
PhN disrupts angiogenesis. Forty-eight hpf Tg(fli1:eGFP) embryos treated from 24 to 48 hpf with either: (A) vehicle alone; or various concentrations of PhN (B-D), illustrating: (B) "Normal"; (C) "Mild"; and (D) "Severe" disruption of angiogenesis. The DLAV is indicated with an arrowhead in (B,C); and examples of disrupted angiogenesis are highlighted with asterisks; (E) Summary of blind scoring of 40 embryos exposed to vehicle alone, 96 embryos exposed to 5 µM PhN, 102 embryos exposed to 10 µM PhN, 91 embryos exposed to 25 µM PhN, and 77 embryos exposed to 40 µM PhN.
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