ZFIN Image: Dozawa et al., 2014, Fig. 7

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Fig. 7

HDAC inhibitor upregulates Notch signaling, which suppresses cell proliferation in the optic tectum of adult zebrafish

A: Timeline of drug treatment. B: Method of quantification of cell number. C: Number of PCNA-positive cells (control: n = 4; inhibitor: n = 8). D: Number of BrdU-positive cells (P = 0.098, control: n = 4; inhibitor: n = 4). E: Number of PCNA-positive cells in 10 caudal slices (control: n = 4; inhibitor: n = 8). F: Number of BrdU-positive cells in 10 caudal slices. Notch inhibitor LY411575 increased the number of proliferating cells (control: n = 4; inhibitor: n = 4). G: Number of BrdU and PCNA double-positive cells in 10 caudal slices (control: n = 5; inhibitor: n = 3). H: Percentage of BrdU and PCNA double-positive cells in PCNA-positive cells in 10 caudal slices; LY411575 did not affect the speed of cell cycle (P = 0.33; control: n = 5; inhibitor: n = 3). I: Timeline of drug treatment. J: Number of BrdU-positive cells from 10 caudal slices (control: n = 2; inhibitor: n = 2). K: Percentage of BrdU and HuC double-positive cells within the number of BrdU-positive cells in 10 caudal slices (control: n = 2; inhibitor: n = 2). **P < 0.01, *P < 0.05.

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