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Fig. 3
Neuroblastomas arise from sympathetic neuroblast precursors in MYCN transgenic fish with loss of nf1.
H&E staining of sagittal sections through the tumors in the IRG of nf1a+/+;nf1b+/+;MYCN;GFP (A), nf1a+/-;nf1b+/+;MYCN;GFP (B) and nf1a-/-;nf1b+/+;MYCN;GFP (C) fish at the age of 6 weeks. Immunohistochemical analysis of neuroblastoma markers tyrosine hydroxylase (TH, D-F) and Hu (G-I) expression on sagittal sections through tumors in the IRG of nf1a+/+;nf1b+/+;MYCN;GFP (D,G), nf1a+/-;nf1b+/+;MYCN;GFP (E,H) and nf1a-/-;nf1b+/+;MYCN;GFP (F,I) fish at the age of 6 weeks.
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