IMAGE

Fig. 2

ID
ZDB-IMAGE-160505-13
Source
Figures for Tan et al., 2016
Image
Figure Caption

Fig. 2

HEXIM1 Activity Suppresses Melanoma In Vivo

(A) 19-week-old Tg(mitfa:BRAFV600E);p53-/-;mitfa-/- zebrafish are shown with rescued melanocytes expressing tumor accelerator SETDB1, background control EGFP, or HEXIM1/hexim1 in the MiniCoopR system.

(B) Tumor-free survival curves for EGFP, SETDB1, and HEXIM1/hexim1 MiniCoopR zebrafish over 25 weeks. Percentages of the total number of zebrafish that were tumor free each week are plotted.

(C) Tumor-free survival curves for MiniCoopR overexpression of human HEXIM1-4A, and HEXIM1-4D are shown.

(D) Tumor-free survival curves for MiniCoopR expression of p53 and hexim CRISPRs are shown.

(E) Tumor growth rates of individual mouse xenografts with a Tet-On HEXIM1-inducible A375 cell line (A375-HEXIM1) over 14 days. Mice were fed either a standard diet or doxycycline diet (mean of seven replicates ± SD).

See also Figure S2.

Figure Data
Acknowledgments
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