ZFIN Image: Cofer et al., 2016, Fig. 5

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Figure Caption

Fig. 5

Biliary defects in zebrafish larvae injected with PDGF-AA peptide. (A) Larvae were injected with PDGF-AA, PDGF-AB, or PDGF-BB peptide at 2 dpf. PED-6 gallbladder uptake, showing the proportion of larvae at 5 dpf with normal, faint, and absent gallbladders (GB). Note the effect of PDGF-AA on biliary function, as depicted by the increase in faint and absent gallbladders (**pd .0001), while the effect of PDGF-AB (p≤.04) and PDGF-BB (p≤.02) is milder. (B) Confocal projections of cytokeratin immunostaining of livers from 5 dpf control (cont) and PDGF-AA (PDGF)-injected larvae. The bile ducts are fewer and less complex in the PDGF-injected liver (as quantified in Table 3).

Acknowledgments

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