ZFIN Image: Takacs et al., 2016, Fig. 5

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Figure Caption

Fig. 5

Transplanted MZdicer cells display reduced ability to integrate into wildtype neuroepithelium. (A) At midblastula stage, ~50 cells (WT or MZdicer) were transplanted into equivalently staged WT embryos. (B) MZdicer clones that display unilateral distribution (asterisk) and/or segregation away from wildtype epithelium (arrowhead). Arrows demarcate a MZdicer clone that displays normal cell shape and bilateral distribution. (C and D) Unilateral MZdicer clone that is organized around ectopic apical membrane (localized aPKC signal; arrowhead in panel D). (E and F) Transverse views of wildtype clone (E) and MZdicer clone (F) displaying epithelial integration and bilateral distribution. (G) Transverse view of MZdicer progeny cells excluded from the neuroepithelium. (H and I) Inset of panel F.

Acknowledgments

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Reprinted from Developmental Biology, 409(2), Takacs, C.M., Giraldez, A.J., miR-430 regulates oriented cell division during neural tube development in zebrafish, 442-50, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.