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Fig. 1
Expression of insulin and insulin receptors during zebrafish endoderm development. (A) In situ hybridization for insra and insrb in the developing zebrafish embryos. (B–C) Fluorescent in situ hybridization of insrb (red) in Tg(sox17:GFP) endoderm (green) at 48 hpf. Abbreviations: z, zygote; ed, endoderm; p, pancreas; li, liver; in, intestine.
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Reprinted from Developmental Biology, 409(2), Ye, L., Robertson, M.A., Mastracci, T.L., Anderson, R.M., An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration, 354-69, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.