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Fig. 3
Open neural tube phenotype is fully penetrant upon treatment with SB505124 at concentrations of 10 µM and higher. All embryos were treated with the indicated concentration of SB505124 at 3.8 hpf (high oblong stage). First column: anterior to the left and dorsal to the top. Scale bar: 250 µm. Second column: frontal views. Scale bar: 100 µm. Arrowheads point to the eye. Third–fifth columns: Embryos were assayed for otx5 expression in the pineal. Dorsal views, anterior to the top. Scale bar: 50 µm. Refer to Table 2 for quantitative data.
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