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Fig. S6 All Notch-responsive cells in the adult pancreas are CACs. Notch active cells in Tg(Tp1:VenusPest) adult fish were labeled with anti-GFP to visualize VenusPest (green) and the ductal marker 2F11 (red). VenusPest labeling is detected throughout the exocrine tissue (see asterisks highlighting examples) and where it highlights the CACs together with 2F11. In contrast, ductal structures with intense 2F11 staining do not exhibit any Venus+ (Notch on) cells. Note also the presence of 2F11 in endocrine islet cells as previously reported [79].
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