ZFIN Image: Frese et al., 2015, Fig. 6

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Fig. 6

Correctly balanced huG and actn3a isoform expression is essential for proper heart function. (A,B) Lateral view of a MO-huG-injected (MO-zhug) zebrafish embryo at 48hpf. Fractional shortening (FS) shows a progressive reduction of cardiac contractility. Inset, cDNA splice-site analysis of huG morphant. (C,D) Splice-site blockage in actn3a leads to mild cardiac dysfunction. actn3a-depleted zebrafish embryos develop heart failure with dilation of the atrium and reduced ventricular contractility beginning at the 72h developmental stage. Inset, cDNA splice-site analysis of actn3a morphant. Results in B and D are mean±s.d. (n=10).

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.