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Fig. S5
MTZ treatment induced apoptosis specific to myocardial cells in myl7:mCherry-NTR embryos.
Whole-mount immunostaining for kdrl:GFP (first column) to show endocardium, MF-20 (second column) to show myocardium, and activated cleaved Caspase-3 (third column) to show apoptotic cells, at 36 hpf. Embryos were treated under the same conditions, in the presence of 1% DMSO (A) or of metronidazole (B), to induce cell specific apoptosis in myl7:nitroreductase expressing myocardial cells. Note that MTZ treated embryos had caspase-positive cardiac cells that are specifically in the myocardial (B, arrowheads, right column) and not the endocardial layer.
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