ZFIN Image: Gallardo et al., 2015, Fig. 4

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Fig. 4

Blocking the Src signaling pathway inhibits collective cell migration in vivo. Cldnb:EGFP embryos were treated at 36hpf (primordium has migrated beyond the yolk extension, dashed line) with the c-Src inhibitors Emodin (B), RBI (C) or SU6656 (D). Treated embryos show a disruption of the primordium migratory ability compared with DMSO control (A), resulting in a phenotype with a premature deposition of a terminal neuromasts (L6) in all conditions (B-D). (E) Quantification of average position of the last five deposited neuromasts in drug treated-embryos relative to the distance from the ov to the tip of the tail. Arrows indicate the position of the PLLp. Experiments were carried out with ten larvae per condition. Error bars indicate +s.d.; ***P<0.001.

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Acknowledgments

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