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Fig. 7
Whole mount in situ hybridization of cyclinD1 (ccnd1) expression changes when dmbx1 is perturbed. Between 48 and 72 hpf, ccnd1 expression was detected in the CMZ region in control embryos (A and D) but in dmbx1 MO-injected embryos, expression had expanded from the CMZ to the central retina (B and E). When dmbx1 was ectopically expressed, there was a strong reduction of ccnd1 expression around the CMZ region (C and F).
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Reprinted from Developmental Biology, 402(2), Wong, L., Power, N., Miles, A., Tropepe, V., Mutual antagonism of the paired-type homeobox genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression, 216-28, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.