ZFIN Image: Burrows et al., 2015, Fig. 5

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Figure Caption

Fig. 5

Smed-med14 Is Required for Tissue Homeostasis and Regeneration in Planarians

(A–F) med14(RNAi) animals show defects in homeostasis, with head regression (yellow arrowheads) and ventral curling apparent in 100% of cases by 3fd10.

(G and H) By 3fd12–15, head and tail regression (yellow and red arrowheads) and the beginnings of lysis are apparent in 100% of med14(RNAi) animals, similar to what is observed following irradiation-mediated depletion of the stem cell pool.

(I–L) In trunk fragments that are regenerating a head (yellow arrowhead) and a tail (red arrowhead), no regeneration is observed by 7 dpa in med14(RNAi) animals.

Scale bars, 100 µm.

Acknowledgments

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