|
Fig. 7
Wnt Signaling Is Required to Suppress dHbl Character in Right-Sided Neurons at the Onset of Tcf7l2 Expression
(A–B′, D, and D′) Dorsal views with anterior to the top of 4 dpf embryos showing the upregulation of kctd12.1 expression in the right habenula of a heat-shock-treated GFP+ Tg(hsp70:Δtcf-GFP) embryo (A′). The pku588 transgene and kctd12.1 are upregulated on the right side in IWRendo-treated embryos (B2 and D2). Control embryos were heat shocked or treated with IWRexo (A, B, and D).
(C) Graph showing timing of IWRendo treatment and percentage of embryos with increased kctd12.1 expression in the right habenula.
See also Figure S5 and Table S4.