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Fig. 7 Impairment of Schwann cell migration following treatment with AG1478. (A) Normal distribution of Schwann cells in a 3 dpf control foxD3:GFP larva. (B) Total absence of Schwann cells in 3 dpf foxD3:GFP/Cxcr4:mCherry larvae treated with 5 µM AG1478 from 10 to 58 hpf (in this double transgenic, neuromasts are labeled in red fluorescence and Schwann cells in green). The supernumerary neuromasts that form in the absence of glial cells are indicated by arrowheads. (C) Partial absence of Schwann cells in 3 dpf foxD3:GFP larvae treated with 3.5 µM AG1478 from 24 to 58 hpf. With this treatement the Schwann cells migrate as far as the posterior end of the trunk (±two somites), but not into the tail at 3 dpf. Scale: A-C: 100 µm.